if your answer is no ,tell me why?
30 Sep 2011
Dear Vasa... may I please ask u why u want to know this?? Propofol (also known as Diprivan) is an anesthetic induction drug. It can also b used for sedation in small doses to keep the patient breathing on their own. The only other instances for it's usage is in ICU units when a patient is on a ventilator to keep the patient calm and asleep while being mechanically ventilated.
Remifentanyl is an ultra short acting form of the drug, fentanyl (also called sublimaze). It is usually used in very short procedures.
And yes, remifentanyl can be injected into an IV with propofol running, like in a propofol drip.
I am just curious why you want to know this. Propofol, when given in larger dosages makes a person apneic (not breathing). It should never be administered by anyone who is not trained and proficient in airway management.
I hope u r asking this for educational purposes and not interested in administering it to someone.
I hope this helps. Please b careful. Pup
29 Sep 2011
Here is what I found in literature re:propafol
Compatibility and Stability: DIPRIVAN (propofol) Injectable Emulsion should not be mixed with other therapeutic agents prior to administration.
Dilution Prior to Administration: DIPRIVAN (propofol) Injectable Emulsion is provided as a ready- to-use formulation. However, should dilution be necessary, it should only be diluted with 5% Dextrose Injection, USP, and it should not be diluted to a concentration less than 2 mg/mL because it is an emulsion. In diluted form it has been shown to be more stable when in contact with glass than with plastic (95% potency after 2 hours of running infusion in plastic).
Administration with Other Fluids: Compatibility of DIPRIVAN (propofol) Injectable Emulsion with the coadministration of blood/serum/plasma has not been established. (See WARNINGS.) When administered using a y-type infusion set, DIPRIVAN (propofol) Injectable Emulsion has been shown to be compatible with the following intravenous fluids.
5% Dextrose Injection, USP
Lactated Ringers Injection, USP
Lactated Ringers and 5% Dextrose Injection
5% Dextrose and 0.45% Sodium Chloride Injection, USP
5% Dextrose and 0.2% Sodium Chloride Injection, USP
Here is what I found about remifentanil
Compatibility With Other Therapeutic Agents: ULTIVA (remifentanil) has been shown to be compatible with DIPRIVAN® (propofol) Injection when coadministered into a running IV administration set. The compatibility of ULTIVA (remifentanil) with other therapeutic agents has not been evaluated.
So it can be given together if you are running an IV. I could not find anything on administering together in a syringe.
You might consult a pharmacist for a better answer.
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