Can Venlafaxine and Desipramine be taken together?

30 Aug 2009

It isn't a good idea since both drugs work on seratonin. In combination they could cause seratonin syndrome which can be fatal. Venlaxafine is an SNRI and Desipramine is tryciclic. If you are taking both together your doctor needs to keep a close eye.

20 Sep 2009

Ditto on 1bobbielou's post--that is not something you want to do. If you are trying to decide between which ONE of the two to take, you should talk to your doctor. Venlafaxine (Effexor) affects both serotonin and norepinephrine, whereas tricyclics affect all 3 of the monoamines (serotonin, norepinephrine, AND dopamine).
As I said already, it's best to speak with your doctor about this one... particularly as either may potentially exacerbate your problem. Also, since Effexor is not an SSRI, however, you might want to look-up IBS-M and SNRIs. My instinct tells me that in terms of the actual type of antidepressant you take, your diet and water intake are going to affect the symptoms of your IBS in a much more pronounced/significant manner. Everybody is different as well, so always be prepared for the unexpected!
Good luck with your situation... I hope it all works out well for you in the end!
Take care,
Kiera