3 May 2010
The presence of antibodies reduces the efficacy of subsequent doses of streptokinase and increases the potential for anaphylaxis.
"... Repeat administration
Because of increased likelihood of resistance caused by antistreptokinase antibodies, streptokinase may not be effective if administered within 5 days to 12 mo of prior streptokinase or anistreplase administration, or streptococcal infections (eg, streptococcal pharyngitis)."
Read more: http://www.drugs.com/ppa/streptokinase.html#ixzz0mp9OAFUM
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