19 Nov 2011
Interactions between your selected drugs
cyclobenzaprine ↔ tramadol
Applies to: cyclobenzaprine, tramadol
MONITOR CLOSELY: The risk of seizures may be increased during coadministration of tramadol with any substance that can reduce the seizure threshold, such as selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), monoamine oxidase inhibitors, neuroleptic agents, central nervous system stimulants, opioids, tricyclic antidepressants, other tricyclic compounds (e.g., cyclobenzaprine, phenothiazines), carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, and theophylline. These agents are often individually epileptogenic and may have additive effects when combined. Many of these agents also exhibit CNS- and/or respiratory-depressant effects, which may be enhanced during their concomitant use with tramadol.
MANAGEMENT: Caution is advised if tramadol is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with epilepsy, a history of seizures, or other risk factors for seizures (e.g., head trauma, brain tumor, metabolic disorders, alcohol and drug withdrawal, CNS infections).
Other drugs that your selected drugs interact with
cyclobenzaprine interacts with more than 300 other drugs.
tramadol interacts with more than 300 other drugs.
Interactions between your selected drugs and food
No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
I suggest you speak to a Dr. with regards to this major interaction.
Take care and be careful,
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1 answer • 1 Feb 2010
I thought that i read that cyclobenzaprine will not relieve pain or work anymore after a two week period.
1 answer • 28 Aug 2010
I generally have 1-2 migraines per week. I have been taking Cyclobenzaprine for a month for neck pain. (pulled muscle?) I have noticed since being on ...
2 answers • 9 Dec 2011
... tolerance to it? Or does it work over time I am reducing the tramadol but want to know if anyone finds Flexeril effective for long time use
1 answer • 31 Jul 2013