3 Nov 2010
Interactions between your selected drugs
No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
Other drugs that your selected drugs interact with
ciprofloxacin interacts with more than 300 other drugs.
Alcohol (contained in alcoholic beverages) (ethanol) interacts with more than 300 other drugs.
Interactions between your selected drugs and food
ciprofloxacin ↔ food
Applies to: ciprofloxacin
ADJUST DOSING INTERVAL: Concurrent ingestion of dairy products (milk, yogurt) or calcium-fortified foods (i.e., cereal, orange juice) may decrease the activity of certain oral fluoroquinolone antibiotics. The mechanism is chelation of calcium and the quinolone, resulting in decreased bioavailability. In the case of orange juice, inhibition of intestinal transport mechanisms (P-glycoprotein or organic anion-transporting polypeptides) by flavones may also be involved. One study reported an average 41% decrease in maximum plasma concentrations and a 38% decrease in AUC when ciprofloxacin was given with calcium-fortified orange juice instead of water.
MANAGEMENT: Dairy products or calcium-fortified foods should be ingested at least 2 hours after or 6 hours before fluoroquinolone administration.
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