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Can constant use of diphenhydramine cause liver or kidney damage?

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5 Aug 2009

No, Diphenhydramine should not cause liver or kidney damage if given at recommended doses (ie 25mg to 50mg up to 4 times day) for a long period of time. However long term use of diphenhydramine is not recommended.

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sohisonia 18 Oct 2010

Yes it can damage your liver b/c most of it metabolizes in the liver.

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