8 May 2011
I realize this answer is very late but may help someone in future.
Nebivolol is metabolized by a number of routes, including glucuronidation and hydroxylation by CYP2D6. The active isomer (d-nebivolol) has an effective half-life of about 12 hours in CYP2D6 extensive metabolizers (most people), and 19 hours in poor metabolizers and exposure to d-nebivolol is substantially increased in poor metabolizers. This has less importance than usual, however, because the metabolites, including the hydroxyl metabolite and glucuronides (the predominant circulating metabolites), contribute to β-blocking activity.
It takes 5.5 x elimination half life for a medicine to be cleared from ones system. Therefore if we use the longer half life of 19 hours then it should take approximately 105 hours (5.5 x 19 hours) for Bystolic to be cleared from ones system.
- Bystolic Information for Consumers
- Bystolic Information for Healthcare Professionals (includes dosage details)
- Side Effects of Bystolic (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Has anyone been on metroprolol that is now on bystolic and finds it anymore effective or with less side effects? I'm 26 and have a genetic ...
6 answers • 8 May 2010
Does anybody can say a good word about Bystolic?
1 answer • 3 May 2012
Even when taking Clais no affect what can I do I'm 57 Years old this can not be happening.
1 answer • 30 Nov 2012