... taking bayer with those two pills and are there serious side effects that can happen from taking those two pills
26 Apr 2011
Let me first explain that Darvon (propoxyphene) was removed from the market in the US in November of 2010. The following explains why:
Darvon or Propoxyphene has been associated with 2,110 reported accidental deaths in the United States since 1981. A large proportion of these deaths occur because most of the drug is converted into a metabolite that is highly toxic to the heart and lasts longer in the body than the original compound, resulting in cardiac depression. Adverse cardiac events associated with propoxyphene include an interruption of heart transmission of electrical impulses, slowed heartbeats and a decreased ability of the heart to contract properly.
If you are still taking Darvon or Darvocet please contact your doctor and discuss the potential harm to your heart.
As fas as the interaction withMetoprolol and aspirin with Darvon, please read the following:
metoprolol ↔ propoxyphene
Applies to: metoprolol, Darvon (propoxyphene)
MONITOR: Propoxyphene may increase the serum levels of some oral beta-blockers. The proposed mechanism is inhibition of CYP450 2D6 first-pass metabolism and decreased hepatic clearance. Data are available for metoprolol and propranolol only; however, other hepatically metabolized beta-blockers may also be affected. Renally excreted beta-blockers such as atenolol, carteolol, nadolol, or sotalol are not expected to interact.
MANAGEMENT: Patients receiving this combination should be monitored for hypotension, heart failure, bradycardia, arrhythmias, and mental status changes when propoxyphene is added to the patient's medical regimen, and for decreased beta-blockade when propoxyphene is deleted from the regimen. A reduction in beta-blocker dosage may necessary.
metoprolol ↔ aspirin
Applies to: metoprolol, Aspirin Low Strength (aspirin)
High doses of salicylates may blunt the antihypertensive effects of beta-blockers. The proposed mechanism is inhibition of prostaglandin synthesis. Low-dose aspirin does not appear to affect blood pressure. In addition, beta-blockers may exert an antiplatelet effect, which may be additive with the effects of some salicylates. Metoprolol may also increase aspirin absorption and/or plasma concentrations of salicylates; however, the clinical significance of this effect is unknown. Data have been conflicting. Until more information is available, patients who require concomitant therapy should be monitored for altered antihypertensive response whenever a salicylate is introduced or discontinued, or when its dosage is modified.
The interactions involve the dosage of the Metoprolol and is probably being taken into consideration by the prescribing doctor. When you remove the darvon from the drug combination the metoprolol may need to be adjusted in strength. You can not stop the darvon abruptly. You maust taper off this medication slowly over time. It is addictive and you will experience withdrawals if you try to stop to quickly.
Please contact your doctor as soon as possible and discuss the information provided.
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