Are there any drugs that are incompatible with digoxin?

Many drugs can interact with digoxin. Below is just a partial list
• alprazolam (Xanax);
• antacid, or Kaopectate
• cancer medications;
• clonidine (Catapres);
• supplements or medications that contain calcium;
• a diuretic (water pill), such as spironolactone (Aldactone, Aldactazide);
• amphotericin B (Fungizone, AmBisome, Abelcet);
• cholestyramine (Questran, Prevalite);
• epinephrine (EpiPen);
• guanabenz (Wytensin) or guanfacine (Tenex);
• indomethacin (Indocin);
• isoproterenol (Isuprel);
• itraconazole (Sporanox);
• levothyroxine (Synthroid, Levothroid, and others);
• methyldopa (Aldomet);
• metoclopramide (Reglan);
• neomycin (Mycifradin, Neo-Fradin, Neo-Tab);
• rifampin (Rifadin, Rifater, Rifamate);
• sulfasalazine (Azulfidine); or

Expand this post...

• an antibiotic such as erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), clarithromycin (Biaxin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);
• a beta-blocker such as carvedilol (Coreg), metoprolol (Lopressor, Toprol), and others;
• a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nisoldipine (Sular), verapamil (Calan, Covera, Isoptin, Verelan), and others;
• decongestant cold or allergy medicine, or nasal sprays such as Afrin, Duramist, Neo-Synephrine, Tysine Nasal, and others;
• a heart rhythm medication such as amiodarone (Cordarone, Pacerone), propafenone (Rythmol), or quinidine (Quinaglute, Quinidex, Quin-Release); or
• steroids such as prednisone, fluticasone (Advair), mometasone (Asmanex, Nasonex), dexamethasone (Decadron, Hexadrol) and others.
This list is not complete and there are many other medicines that can interact with digoxin.