I've had panic disorder (along with depression, OCD, PTSD, major anxiety... ) since childhood. I'm on an anti-depressant now. I've been on most all of the anti-depressants out there and my dr. has now told me that I'm resistant to the anti-depressants. I was on Klonopin years ago (at two different times in my life). The first time I did not gain weight and it worked wonderfully! The second time I was on it I gained a LOT of weight. I'm having a horrible time with major depression and almost constant depression and want to try the Klonopin again, but am afraid of the weight gain. Any feedback would be greatly appreciated. Thanks!