I was on Serzone for years until they quit making it. My doctor put me on cymbalta and I absolutely love how it made me feel. I started noticing that I was having muscle cramps a lot. Finally the cramps got to be so bad that I talked to my doctor about it. He changed my medication to Pristiq and I have been on it for 6 days now. I noticed a decrease in the muscle cramps for a few days, but yesterday and last night were one of the worse days ever. Does anyone else suffer muscle cramps from either of these medications? I am at wits end. I have cramps in places I didn't even know I had muscles. So so painful.
13 Sep 2012
Hello kytracer. I did some researching on your question. Both come from the same family of drugs (SNRI) But I found nothing in regards to leg cramps on either drug. I was on Cymbalta for several years and in my case it wasn't an issue. Now in regards to Pristiq, muscle pain is reported in between 2to 5% of people taking the drug. If it persists, I'd speak to your doctor for theres no guarantee that the cramps/aches are going to lessen or diminish. Regards pledge
10 Jun 2015
I've been on Pristiq for a couple of years and have noticed that in the last year, I've had increasingly more and more severe leg cramps. Sometimes I have much pain with standing, sitting and walking. When going from standing to squatting and standing up from squat position my legs almost give out. I just Googled Pristiq and leg cramps and am relieved to see other people are experiencing the same symptoms so this may explain mine.
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