Was anyone offered the use of the less-expensive patent-expired Taxotere in lieu of this drug? Are they pushing it only because it has a patent and costs far more than the alternatives? Or is it really that much more effective?
15 Sep 2012
Both Abraxane and Taxotere are taxanes.
The chemical name for Abraxane is albumin-bound paclitaxel and the chemical name for Taxotere is docetaxel.
They are not equal. Crudely, you could say, one is an apple and the other an orange. They are both fruit, but they are different fruits.
To understand the relationship, one can look to Taxol (chemical name: paclitaxel).
Taxol is an extract from the bark of the Pacific yew, a rare tree.
Taxotere is made by esterifying the extract of the more abundant European Yew tree. So, Taxotere is a semi-synthetic analogue of Taxol.
Abraxane is albumin-bound Taxol.
Therefore, Abraxane and Taxotere are NOT identical. Abraxane also does not contain the solvents that Taxol and Taxotere do, which reportedly increases tolerance, among other things.
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