13 Aug 2010
Hello, the warning is major..meaning combining both of them is dangerous.
Interactions between your selected drugs
citalopram ↔ 5-hydroxytryptophan
Applies to: citalopram, 5-HTP (5-hydroxytryptophan)
GENERALLY AVOID: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.
MANAGEMENT: The concomitant use of serotonin reuptake inhibitors and tryptophan should be avoided.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Patient has been on Lexapro for several months, and recently began taking 5 HTP. Is there any danger of a drug interaction?
1 answer • 13 Sep 2010
Tryptophan - Was on 300 mgs 5-HTP for about 1mo; coming off Opana's to Methadone-MY CHOICE - after 6
Trying to find out more info about L-trytophan... Had tried 5htp while I was going down from Opana's to Methadone - MY DECISION; I refused to ...
3 answers • 30 Mar 2011
I'm repeating this with change to conversation rather than one answer. Thought maybe somebody would see it and answer if I changed to ...
3 answers • 17 Dec 2011
I recently came off 60mg of Citalopram for depression and anxiety and moved onto Sertraline by my doc. I'm currently on 100mg of Sertraline, my ...
2 answers • 6 Jul 2012