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March 2009

March 2

Study Showing Improved Virologic Response with Nitazoxanide in Chronic Hepatitis C Published in Gastroenterology Hana Biosciences Announces Successful Planned Independent Safety Analysis Supports Ability to Complete Pivotal rALLy Clinical Trial of Marqibo, Its Lead Novel Anti-Cancer Compound Astellas and XenoPort Announce Positive Results from Phase 2 Trial of ASP8825/XP13512 in Japan for Restless Legs Syndrome Nektar Announces Positive Results from Phase 2 Study of Oral NKTR-118 in Patients with Opioid-Induced Constipation (OIC) Bionovo Announces Publication of Positive Phase 2 Trial Results for Menerba NanoBio to Announce Key Clinical and Preclinical Data on Its Topical Anti-infective Lotions at AAD 2009 Anacor to Present Clinical and Preclinical Data on Topical Anti-Inflammatory and Anti-Fungal Candidates, AN2728, AN2898 and AN2718, at the American Academy of Dermatology Annual Meeting New head-to-head data published in The Lancet: Prasugrel reduces cardiovascular event risk in high-risk heart attack patients when compared to clopidogrel

March 5

Opexa Provides Key Quality of Life Data on Tovaxin for Multiple Sclerosis Access Pharmaceuticals Announces Positive ProLindac Phase 2 Ovarian Cancer Clinical Trial Results Lexicon Presents Clinical Data on LX1032 for Carcinoid Syndrome at European Neuroendocrine Tumor Society Meeting Isolagen, Inc. Reports Positive Top-line Results from Phase II/III Study of Isolagen Therapy to Treat Moderate to Severe Acne Scars: Study Meets All Primary Efficacy Endpoints and is Statistically Significant CV Therapeutics Reports Phase 1 Data Showing Proof of Concept for CVT-3619, a Novel Potential Treatment for Cardiometabolic Diseases Cypher Sirolimus-eluting Coronary Stent Demonstrates Sustained Benefits Compared to Bare-Metal Stents in Six-Year Randomized Clinical Trial The Texas Institute of Dermatology Team Finds Easy-to-Apply, Topical Drug Just as Good as Injectable Compound for a Disfigurating Skin Infection

March 16

Concert Pharmaceuticals Announces Positive Results from Phase I Clinical Study of CTP-347 Oncolytics Biotech Inc. Announces Reovirus Research to be Presented at AACR Annual Meeting Clavis Pharma ASA (NO) - Clavis Pharma Announces Positive Elacytarabine Phase II Results New, Published Gelnique Data Show Efficacy, Convenience and Excellent Tolerability C1-Esterase Inhibitor Concentrate Rapidly Relieves Acute Swelling Attacks Across All Body Sites in Patients with Hereditary Angioedema, According to Study Avexa Reports Positive 96 Week Data for HIV Drug Apricitabine (ATC) CyDex Pharmaceuticals Presents Phase 2 Clinical Trial Results for Captisol-Enabled Budesonide/Azelastine Combination Solution Nasal Spray at American Academy of Allergy Asthma and Immunology (AAAAI) Meeting CytRx's Arimoclomol Demonstrates Statistically Significant Neurorestorative Results in a Preclinical Embolic Stroke Trial DURECT Reports Positive Phase IIb Data from TRANSDUR-Sufentanil Clinical Program Adult Stem Cell Study Demonstrates Improved Quality of Life for Patients Suffering from Spinal Cord Injury New, published data demonstrate effectiveness/excellent tolerability for first topical OAB treatment Provectus PV-10 Interim Phase 2 Safety and Efficacy Results are as Good as or Better than Phase 1 Results Unigene Reports Positive PTH Clinical Study Results Data Presented at AAAAI Reinforce Baxter's Commitment to Making GAMMAGARD LIQUID Therapy More Convenient

March 19

March 26

Ezetimibe and Ezetimibe/Simvastatin Combo Pose No Increased Cancer Risk, Study Shows Celtic Pharma - Successful Outcome of Phase II Trial for Topical Treatment of Onychomycosis Neurocrine Announces Top-Line Results From 702 Study (Lilac PETAL Study) of Elagolix for Treatment of Endometriosis Pain Positive Phase 3 uveitis trial results for voclosporin reported by Isotechnika's partner Lux Biosciences Reata Completes Financing and Expands Team to Capture Opportunity Created by Encouraging Clinical Data in Chronic Kidney Disease Exenatide Clinical Data Analysis Shows No Increased Risk of Cardiovascular Events Lux Biosciences Reports Positive Results from LUMINATE Phase 3 Program of LX211 (LUVENIQ) in Uveitis Positive Results from Neurotech's NT-501 Phase 2 Dry AMD (Geographic Atrophy) Study Demonstrate Proof of Concept RegeneRx Reports Phase II Venous Stasis Trial Results Hythiam Announces Results of Two Double-Blind, Placebo-Controlled Studies on Impact of Prometa Treatment Program for Alcohol Dependence VGX Pharmaceuticals' Oral Anti-Inflammatory Drug Safe in Phase I Study Boston Scientific Announces Schedule For ACC 2009

March 30

Crestor Reduced Risk of Blood Clots in the Veins Lilly Announces Inconclusive Phase II Study Results for mGlu2/3 at the International Congress on Schizophrenia Research Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal for Fabry Disease at ACMG 2009 Annual Meeting Abbott's Market-Leading XIENCE V Shows Increasing Clinical Advantages Over TAXUS Express2/TAXUS Liberte Between Two and Three Years Arena Pharmaceuticals Announces Positive Lorcaserin Pivotal Phase 3 Obesity Trial Results: Meets All Primary Efficacy and Safety Endpoints New Data for Abbott's TRILIPIX (fenofibric acid) in Combination with Rosuvastatin Calcium Shows Improvement on Key Lipids for Cholesterol Management Arena Pharmaceuticals to Host Conference Call and Webcast on Monday, March 30, 2009 to Discuss Lorcaserin Pivotal Phase 3 Obesity Trial Results Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session SYNTAX Analysis Finds Treatment With TAXUS Express2 Stents More Cost Effective Than Bypass Surgery in Many Patients With Complex Coronary Artery Disease Celsion Announces Promising ThermoDox Clinical Results in Primary Liver Cancer Were Published in Expert Opinion AHRQ-Funded Study Finds Lower Risk of Death and Heart Attack in Patients With Drug-Coated Stent Implants Compared to Those With Bare Metal Stents Data from Gencaro Phase 3 Best Trial Presented at the American College of Cardiology 58(th) Annual Scientific Session Gentium Announces Preliminary Results from a Phase 2/3 European Pediatric Prevention Trial for Veno-Occlusive Disease at the European Group for Blood and Marrow Transplantation Annual Meeting Hyperion Therapeutics Announces Results for Phase II Study in Urea Cycle Disorders Amorcyte Presents Results of Stem Cell Study at ACC on Improved Blood Circulation After Severe Heart Attack Pronova BioPharma ASA (NO) - Findings in the OMEGA study presented Clinical Data Reinforce Safety and Efficacy of Boston Scientific's Two Drug- Eluting Stent Platforms Results From Study Show Promising Efficacy and Safety Results for Corthera's Relaxin in Acute Heart Failure New Lantheus Study Finds Significant Survival Benefit for Critically Ill Patients Undergoing Contrast-Enhanced Echocardiography Comparative Analysis of Four Beta Blocker Trials Presented at the American College of Cardiology 58(th) Annual Scientific Session Combination Adult Stem Cell Therapy Improves Severe Limb Ischemia Spaltudaq Corp. Announces Identification of Broadly and Potently Neutralizing Human HIV Antibodies and Change of Company Name to Theraclone Sciences, Inc. SARcode Announces Results of Phase 1 Trial of SAR 1118 Ophthalmic Solution in Healthy Adult Subjects Schering-Plough Announces Results of the Early ACS Trial Intensive Lipitor Therapy Provided Sustained Risk Reduction Of Cardiovascular Events In Older Patients With Heart Disease

March 31

Karo Bio Reports Positive Results For Kb3305 In Diabetes Patients New analyses of phase 3 data for NicOx’ naproxcinod presented at the American College of Cardiology (ACC) Annual Meeting Significantly More Patients With Cardiovascular Disease Quit Smoking Using Chantix/Champix (Varenicline) Compared With Placebo Plavix Plus Aspirin More Effective Than Aspirin Alone in Preventing Major Vascular Events in Patients with Atrial Fibrillation Who Cannot Take Oral Anticoagulants Zosano Pharma, Inc. to Present Positive Phase 2 Results of Its Transdermal Patch for Osteoporosis Novel PET Myocardial Perfusion Imaging Tracer Data Presented Exenatide Once Weekly Provided Superior Glucose Control With Weight Loss Compared to Sitagliptin or Pioglitazone in Head-to-Head DURATION-2 Study New Study Suggests Rx Estrogen Delivery Through the Skin May Show Safety Benefits as Opposed to Oral Delivery VIA Pharmaceuticals to Present Poster at AHA Arteriosclerosis, Thrombosis and Vascular Biology Conference 2009 New Data Presented at ACC.09 Shows Benefit of Cardiac Resynchronization Therapy in Mildly Symptomatic Heart Failure Patients

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