Lyrica Alternatives Compared
Lyrica | Gabapentin | Cymbalta |
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Lyrica (pregabalin) | Gabapentin | Cymbalta (duloxetine) |
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Prescription only
Lyrica can help relieve nerve pain and control seizures but it is likely to cause drowsiness. Prescribed for Neuropathic Pain, Fibromyalgia, Diabetic Peripheral Neuropathy, Neuralgia, Postherpetic... View more |
Prescription only
Gabapentin may be used in the treatment of partial-onset seizures and nerve pain but is likely to cause dizziness or drowsiness. Gabapentin enacarbil (brand name Horizant), a prodrug of gabapentin... View more |
Prescription only
Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more |
Related suggestions Fibromyalgia
Diabetic Peripheral Neuropathy
Popular comparisons
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More about Lyrica (pregabalin) | More about Gabapentin | More about Cymbalta (duloxetine) | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Lyrica has an average rating of 6.4 out of 10 from a total of 919 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 27% reported a negative effect. |
Gabapentin has an average rating of 7.1 out of 10 from a total of 2516 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 21% reported a negative effect. |
Cymbalta has an average rating of 6.3 out of 10 from a total of 1875 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
See also: Lyrica side effects in more detail. |
See also: gabapentin side effects in more detail. |
See also: Cymbalta side effects in more detail. |
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Generic Availability | ||||||||||||||||||||||||||
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Lyrica prices |
View all gabapentin prices |
View all Cymbalta prices |
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Dosage Form(s) Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
Other pregabalin brands include: Lyrica CR | Fanatrex, Gabarone, Gralise, Neurontin | Other duloxetine brands include: Drizalma Sprinkle, Irenka | ||||||||||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
6.3 hours |
6 hours |
17 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
Some potential for abuse
Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 283 drugs are known to interact with Lyrica:
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A total of 269 drugs are known to interact with gabapentin:
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A total of 592 drugs are known to interact with Cymbalta:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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Disease Interactions | ||||||||||||||||||||||||||
First Approval Date | ||||||||||||||||||||||||||
December 30, 2004 |
December 30, 1993 |
N/A |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.