Avacopan Side Effects
Medically reviewed by Drugs.com. Last updated on Aug 9, 2023.
Applies to avacopan: oral capsule.
Serious side effects of Avacopan
Along with its needed effects, avacopan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking avacopan:
More common
- Bladder pain
- bloody or cloudy urine
- chest pain or tightness
- cough
- dark urine
- difficult, burning, or painful urination
- fever or chills
- frequent urge to urinate
- loss of appetite
- lower back or side pain
- nausea or vomiting
- sneezing
- sore throat
- stomach pain, severe
- trouble breathing
- unusual tiredness or weakness
- yellow eyes or skin
Less common
- Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
Other side effects of Avacopan
Some side effects of avacopan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- diarrhea
- dizziness
- headache
- skin rash
For Healthcare Professionals
Applies to avacopan: oral capsule.
General
The most common adverse reactions occurring in 5% of patients or greater included nausea, headache, diarrhea, vomiting, rash, upper abdominal pain, and dizziness.[Ref]
Cardiovascular
Very common (10% or more): Hypertension (18%)[Ref]
Dermatologic
Very common (10% or more): Rash (11%)
Common (1% to 10%): Alopecia, pruritus, cellulitis, angioedema[Ref]
Endocrine
Common (1% to 10%): Cushingoid[Ref]
Gastrointestinal
Very common (10% or more): Nausea (24%), diarrhea (15%), vomiting (15%)
Common (1% to 10%): Upper abdominal pain, constipation, dyspepsia, oral candidiasis, oral herpes, gastroenteritis[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection[Ref]
Hematologic
Very common (10% or more): Decreased white blood cell count (19%)
Common (1% to 10%): Anemia, leukopenia, lymphopenia, neutropenia, increased tendency to bruise
Uncommon (0.1% to 1%): Agranulocytosis[Ref]
Hepatic
Very common (10% or more): Increased liver function test (up to 13.3%)
Frequency not reported: Hepatitis B reactivation[Ref]
Increased liver function test (LFT) included elevated ALT and bilirubin, abnormal hepatic function, increased gamma-glutamyl transferase, increased hepatic enzyme, and increased transaminase. In another study increased LFT included hepatitis, hepatitis cholestasis, hepatocellular injury, asymptomatic hepatitis, cytolysis, and anicteric cholestasis without hepatocellular insufficiency.[Ref]
Immunologic
Very common (10% or more): ANCA-positive vasculitis (16%)[Ref]
Musculoskeletal
Very common (10% or more): Arthralgia (19%), muscle spasms (11%)
Common (1% to 10%): Back pain, myalgia, pain in extremity[Ref]
Nervous system
Very common (10% or more): Headache (21%)
Common (1% to 10%): Dizziness, paresthesia, tremor[Ref]
Other
Very common (10% or more): Peripheral edema (21%), fatigue (10%)
Common (1% to 10%): Herpes zoster, bruising, increased creatine phosphokinase, pyrexia, otitis media
Uncommon (0.1% to 1%): Weight increased[Ref]
Renal
Common (1% to 10%): Increased serum creatinine, acute kidney injury[Ref]
Respiratory
Very common (10% or more): Cough (16%), nasopharyngitis (15%), upper respiratory tract infection (15%)
Common (1% to 10%): Pneumonia, sinusitis, oropharyngeal pain, bronchitis, epistaxis, dyspnea, lower respiratory tract infection, influenza, rhinitis[Ref]
Psychiatric
Common (1% to 10%): Insomnia[Ref]
More about avacopan
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- Dosage information
- During pregnancy
- Drug class: selective immunosuppressants
- Breastfeeding
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References
1. (2021) "Product Information. Tavneos (avacopan)." ChemoCentryx, Inc.
2. (2023) "Product Information. Tavneos (avacopan)." Vifor Pharma Pty Ltd
3. (2023) "Product Information. Tavneos (avacopan)." Vifor Fresenius Medical Care Renal Pharma UK Ltd
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.