Methadone Alternatives Compared
Methadone | Clonidine | Methocarbamol |
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Methadone | Clonidine | Methocarbamol |
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Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Prescription only
Clonidine can be used to lower blood pressure and treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects. Clonidine should not be stopped suddenly... View more |
Prescription only
Methocarbamol is only given when other treatments for musculoskeletal pain have not worked. Its main side effect is drowsiness and it should not be used in children or seniors. Prescribed for Muscle... View more |
Related suggestions |
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More about Methadone | More about Clonidine | More about Methocarbamol | ||||||||||||||||||||||||
Ratings & Reviews | ||||||||||||||||||||||||||
Methadone has an average rating of 8.7 out of 10 from a total of 595 ratings on Drugs.com. 85% of reviewers reported a positive effect, while 5% reported a negative effect. |
Clonidine has an average rating of 7.2 out of 10 from a total of 755 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 21% reported a negative effect. |
Methocarbamol has an average rating of 6.3 out of 10 from a total of 293 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 30% reported a negative effect. |
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Drug Class | ||||||||||||||||||||||||||
Side Effects | ||||||||||||||||||||||||||
See also: methadone side effects in more detail. |
See also: clonidine side effects in more detail. |
See also: methocarbamol side effects in more detail. |
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Generic Availability | ||||||||||||||||||||||||||
Lower cost generic |
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all methadone prices |
View all clonidine prices |
View all methocarbamol prices |
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Dosage Form(s) Available | ||||||||||||||||||||||||||
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Brand Names | ||||||||||||||||||||||||||
Methadone Diskets, Methadose, Methadose Sugar-Free | Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR | Carbacot, Robaxin | ||||||||||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
30 hours |
15 hours |
2 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||||||||||
A total of 718 drugs are known to interact with methadone:
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A total of 371 drugs are known to interact with clonidine:
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A total of 342 drugs are known to interact with methocarbamol:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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Disease Interactions | ||||||||||||||||||||||||||
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First Approval Date | ||||||||||||||||||||||||||
August 13, 1947 |
September 03, 1974 |
July 16, 1957 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
N/A |
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More Information | ||||||||||||||||||||||||||
Patient resources | ||||||||||||||||||||||||||
Professional Resources | ||||||||||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.