Comparing Hydrocodone vs Methadone
Hydrocodone | Methadone |
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Hydrocodone | Methadone |
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Prescription only
Hydrocodone is a potent pain-relieving medicine; however, its use is limited by its potential for addiction and dependence. It is one of the most misused opioids in the United States. Prescribed for... View more |
Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Related suggestions |
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More about Hydrocodone | More about Methadone | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Hydrocodone has an average rating of 5.6 out of 10 from a total of 196 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 39% reported a negative effect. |
Methadone has an average rating of 8.7 out of 10 from a total of 596 ratings on Drugs.com. 85% of reviewers reported a positive effect, while 5% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: hydrocodone side effects in more detail. |
See also: methadone side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all hydrocodone prices |
View all methadone prices |
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Dosage Form(s) Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Hysingla ER | Methadone Diskets, Methadose, Methadose Sugar-Free | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
8 hours |
30 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 576 drugs are known to interact with hydrocodone:
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A total of 718 drugs are known to interact with methadone:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
N/A |
August 13, 1947 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.